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<channel>
	<title>Israel Trade Commission</title>
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	<link>http://www.israeltrade.org.au</link>
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		<title>Intucell</title>
		<link>http://www.israeltrade.org.au/intucell/</link>
		<comments>http://www.israeltrade.org.au/intucell/#comments</comments>
		<pubDate>Thu, 17 May 2012 05:44:07 +0000</pubDate>
		<dc:creator>ITC Sydney</dc:creator>
				<category><![CDATA[Business Opportunities]]></category>
		<category><![CDATA[IT & Communication]]></category>

		<guid isPermaLink="false">http://www.israeltrade.org.au/?p=11577</guid>
		<description><![CDATA[Intucell was founded in 2008 with a brilliant idea and a mission to change mobile network management as we know it. In less than a year the company turned that idea into a commercial reality. Today, the company’s SON systems are deployed by a number of Tier 1 mobile operators worldwide, consistently exceeding expectations. Intucell [...]]]></description>
			<content:encoded><![CDATA[<p align="left"><span style="font-size: small;">Intucell was founded in 2008 with a brilliant idea and a mission to change mobile network management as we know it. In less than a year the company turned that idea into a commercial reality. Today, the company’s SON systems are deployed by a number of Tier 1 mobile operators worldwide, consistently exceeding expectations. </span></p>
<p>Intucell delivers the world’s most advanced Self Optimizing Network (SON) solution, commercially available for 3G networks today. With Real Time network, Intucell’s system <span style="font-size: small;"><strong><span style="font-family: Calibri,Calibri; font-size: small;"><strong><span style="font-family: Calibri,Calibri; font-size: small;">automatically </span></strong></span></strong><span style="font-size: small;">tunes the network to actual conditions as they develop and change. All our modules work in a closed loop, performing thousands of micro adjustments, dynamically adapting to network and traffic changes with </span><strong><span style="font-family: Calibri,Calibri; font-size: small;"><strong><span style="font-family: Calibri,Calibri; font-size: small;">15min reactivity</span></strong></span></strong><span style="font-size: small;">. </span></span></p>
<p><span style="font-size: small;">Intucell Systems offering includes:</span></p>
<p>- Automatic Neighbor Relations (ANR)<br />
- New Cells Plug &amp; Play<br />
- Dynamic Load Balancing system<br />
- Coverage &amp; Capacity Optimization</p>
<p>The main benefits of implementing Intucell Self Optimizing Networks solution are a significant gain in operational efficiency, KPI improvements, and real time response to network and traffic changes.</p>
<p>With Real Time Visibility of the entire RAN, fully Automatic Optimization and Instant Feedback Loop, Self Optimizing Network is here, today!</p>
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		<item>
		<title>Grand opera at Masada by AJN</title>
		<link>http://www.israeltrade.org.au/grand-opera-at-masada-by-ajn/</link>
		<comments>http://www.israeltrade.org.au/grand-opera-at-masada-by-ajn/#comments</comments>
		<pubDate>Thu, 17 May 2012 04:11:25 +0000</pubDate>
		<dc:creator>ITC Sydney</dc:creator>
				<category><![CDATA[Tourism News from Israel]]></category>

		<guid isPermaLink="false">http://www.israeltrade.org.au/?p=11554</guid>
		<description><![CDATA[Click to read the full Pdf article by Dany Gocs- Travel editor, Australian Jewish News   Click to watch Historic Masada video from JNTV ]]></description>
			<content:encoded><![CDATA[<p><a href="http://www.israeltrade.org.au/wp-content/uploads/2012/05/AJN-Article-Masada-18052012.pdf">Click to read the full Pdf article</a> by Dany Gocs- Travel editor, Australian Jewish News</p>
<p> <a href="http://www.israeltrade.org.au/wp-content/uploads/2012/05/operamasadaarticle.png"><img class="alignnone size-medium wp-image-11566" title="operamasadaarticle" src="http://www.israeltrade.org.au/wp-content/uploads/2012/05/operamasadaarticle-300x151.png" alt="" width="300" height="151" /></a></p>
<p>Click to watch <a href="http://bcove.me/huvcldoc">Historic Masada video from JNTV</a> <br />
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		<item>
		<title>Israel Alternative Energy Solutions @ Intersolar Europe</title>
		<link>http://www.israeltrade.org.au/israel-alternative-energy-solutions-intersolar-europe/</link>
		<comments>http://www.israeltrade.org.au/israel-alternative-energy-solutions-intersolar-europe/#comments</comments>
		<pubDate>Thu, 17 May 2012 00:16:32 +0000</pubDate>
		<dc:creator>ITC Sydney</dc:creator>
				<category><![CDATA[Events & Exhibitions]]></category>
		<category><![CDATA[Israeli National Pavilions Abroad]]></category>
		<category><![CDATA[Upcoming Events]]></category>
		<category><![CDATA[Upcoming Exhibitions]]></category>

		<guid isPermaLink="false">http://www.israeltrade.org.au/?p=11532</guid>
		<description><![CDATA[Israel will be hosting a NAtional Pavillion at the Intersolar Expo in Munich, Germany from 13th &#8211; 15th June 2012. &#160; To view the profiles of the participating Israeli companies please click here]]></description>
			<content:encoded><![CDATA[<p><a href="http://www.israeltrade.org.au/wp-content/uploads/2012/05/newtech-brainpower.jpg"><img class="alignnone  wp-image-11539" title="newtech popup eng" src="http://www.israeltrade.org.au/wp-content/uploads/2012/05/newtech-brainpower-150x150.jpg" alt="" width="224" height="175" /></a></p>
<p>Israel will be hosting a NAtional Pavillion at the Intersolar Expo in Munich, Germany from 13th &#8211; 15th June 2012.</p>
<p>&nbsp;</p>
<p>To view the profiles of the participating Israeli companies please <a href="http://www.israeltrade.org.au/wp-content/uploads/2012/05/InterSolar-1_12.pdf">click here</a></p>
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		<title>Ltea Biopharma Ltd.</title>
		<link>http://www.israeltrade.org.au/ltea-biopharma-ltd/</link>
		<comments>http://www.israeltrade.org.au/ltea-biopharma-ltd/#comments</comments>
		<pubDate>Wed, 16 May 2012 02:07:30 +0000</pubDate>
		<dc:creator>ITC Sydney</dc:creator>
				<category><![CDATA[Business Opportunities]]></category>
		<category><![CDATA[Life Science]]></category>
		<category><![CDATA[vistech]]></category>

		<guid isPermaLink="false">http://www.israeltrade.org.au/?p=11521</guid>
		<description><![CDATA[Lutea Biopharmaceuticals Ltd. is specialized in development of novel therapeutics for cancer and inflammatory diseases. Our drug candidates – the NUP, target a cellular protein NF-κB (nuclear factor kappa &#8211; B cells), Lutea&#8217;s NUP has been investigated for years and was found to be effective in suppressing cancer cells in vitro (Hodgkin’s lymphoma and breast [...]]]></description>
			<content:encoded><![CDATA[<p>Lutea Biopharmaceuticals Ltd. is specialized in development of novel therapeutics for cancer and inflammatory diseases. Our drug candidates – the NUP, target a cellular protein NF-κB (nuclear factor kappa &#8211; B cells), Lutea&#8217;s NUP has been investigated for years and was found to be effective in suppressing cancer cells in vitro (Hodgkin’s lymphoma and breast carcinoma cells) and in vivo (melanoma lung metastases).<br />
Lutea holds a worldwide exclusive license granted by B.G. Negev Technologies and Applications Ltd., the commercial arm of the Ben Gurion University, for developing manufacturing and commercializing this<br />
innovative anti cancer Botanical Drug. Lutea plans to complete the pre-clinical development program and to initiate a clinical trial in cancer patient by mid 2012.</p>
<p>The Opportunity<br />
Cancer prevalence is constantly growing worldwide, including melanomas – approximately a quarter of a million new melanoma patients are predicted every year in the western countries. To date, there is no<br />
effective therapy, and the pursuit after new effective and safe anti melanoma drug is one of the major challenge among the big pharmas, who invest enormous resources in searching for a drug. The recently approved Yervoy, costs $30,000 per infusion and it expands advanced melanoma patients life by an average of 4 month. The safety profile of Yervoy is very poor and it is subject to strict control.<br />
Botanical Drugs (BD) are a major opportunity, as they are entitled for relatively short development pathway, at relatively lower cost and less risks, through the US FDA.</p>
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		<title>EIN HOD ARTISTS&#8217; VILLAGE: A VISIT THROUGH THE PAST AND THE PRESENT</title>
		<link>http://www.israeltrade.org.au/ein-hod-artists-village-a-visit-through-the-past-and-the-present/</link>
		<comments>http://www.israeltrade.org.au/ein-hod-artists-village-a-visit-through-the-past-and-the-present/#comments</comments>
		<pubDate>Wed, 16 May 2012 01:29:34 +0000</pubDate>
		<dc:creator>ITC Sydney</dc:creator>
				<category><![CDATA[Tourism News from Israel]]></category>

		<guid isPermaLink="false">http://www.israeltrade.org.au/?p=11510</guid>
		<description><![CDATA[The picturesque artists&#8217; village of Ein Hod is located on the slopes of Mt Carmel, overlooking the sea and Atlit fortress. It is the only artists&#8217; village in Israel, and one of only a few in the world. The contemporary art exhibited in the village features a range of paintings and sculptures, prints, ceramics, jewelry, [...]]]></description>
			<content:encoded><![CDATA[<p>The picturesque artists&#8217; village of Ein Hod is located on the slopes of Mt Carmel, overlooking the sea and Atlit fortress. It is the only artists&#8217; village in Israel, and one of only a few in the world. The contemporary art exhibited in the village features a range of paintings and sculptures, prints, ceramics, jewelry, textiles, crafts, glasswork and Judaica.</p>
<p>The artists’ village was established in the 1950s, after a group of artists led by the acclaimed Dada artist Marcel Janco conceived the idea of turning the village of Ein Hod into a place where they could work, build studios and workshops, and form a creative environment for art, art education and to enrich the new and developing nation.</p>
<p>Ein Hod is characterized by the unique design of the village, which blends in with its natural surroundings, preserving the original Crusader architecture. Ein Hod remains a natural reserve of traditional Israeli environment, an environment that greatly contributes to creative and fruitful artistic work.</p>
<p>At Ein Hod, visitors will find restaurants, cafés, an art bar for beer lovers, unique B&amp;Bs, and the opportunity to view and purchase unique pieces of art.</p>
<p>Visitors are welcome to take part in several guided tours, artist demonstrations, workshops, lectures, or visit the Nisco Museum of antique music boxes.</p>
<p>For more information:  <strong><a href="http://www.ein-hod.info/" target="_blank">www.ein-hod.info</a></strong></p>
<p> <a href="http://www.israeltrade.org.au/wp-content/uploads/2012/05/Ein-Hod-6.jpg"><img class="alignnone size-thumbnail wp-image-11511" title="Ein Hod 6" src="http://www.israeltrade.org.au/wp-content/uploads/2012/05/Ein-Hod-6-150x150.jpg" alt="" width="150" height="150" /></a></p>
<p>Watch on you tube:<br />
<iframe src="http://www.youtube.com/embed/JZiY4cX0pgk?rel=0" frameborder="0" width="560" height="315"></iframe></p>
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		<title>Israel signed a framework trade accord with Thailand</title>
		<link>http://www.israeltrade.org.au/israel-signed-a-framework-trade-accord-with-thailand/</link>
		<comments>http://www.israeltrade.org.au/israel-signed-a-framework-trade-accord-with-thailand/#comments</comments>
		<pubDate>Tue, 15 May 2012 21:57:50 +0000</pubDate>
		<dc:creator>ITC Sydney</dc:creator>
				<category><![CDATA[Latest News Israel]]></category>
		<category><![CDATA[News]]></category>

		<guid isPermaLink="false">http://www.israeltrade.org.au/?p=11496</guid>
		<description><![CDATA[As reported in Port2Port: The country hopes the accord would assist in developing trade relations with countries in South East Asia   Israel&#8217;s Minister of Industry, Trade and Labor Shalom Simchon and Thailand&#8217;s Deputy Minister of Commerce Poom Sarapol signed last week a framework trade accord intend to further develop bilateral trade and assist Israeli [...]]]></description>
			<content:encoded><![CDATA[<p><strong><a href="http://www.israeltrade.org.au/wp-content/uploads/2012/05/Flag-Pins-Israel-Thailand.jpg"><img class="alignnone size-full wp-image-11497" title="Flag-Pins-Israel-Thailand" src="http://www.israeltrade.org.au/wp-content/uploads/2012/05/Flag-Pins-Israel-Thailand.jpg" alt="" width="400" height="320" /></a></strong></p>
<p><strong>As reported in <a href="http://www.port2port.com" target="_blank">Port2Port</a>: The country hopes the accord would assist in developing trade relations with countries in South East Asia<br />
</strong> <br />
Israel&#8217;s Minister of Industry, Trade and Labor Shalom Simchon and Thailand&#8217;s Deputy Minister of Commerce Poom Sarapol signed last week a framework trade accord intend to further develop bilateral trade and assist Israeli trade with countries in South East Asia.<br />
 <br />
In a statement issued by the ministry, it was noted that the new trade accord will facilitate Israeli trading activity in Thailand, as well as in neighboring countries.<br />
In recent years, Israel has made a great deal of efforts to advance Israeli exports to Thailand, mainly in agriculture, exporting fresh produce, construction, security, communication and electronics.<br />
 <br />
Simchonnoted that Thailand acts as gateway not only to South East Asian countries, but also to Cambodia, Laos and Myanmar.<br />
 <br />
The agreement will, on one hand, facilitate trade with the Asian countries, and on the other hand will allow permanent consultations with the Thai government.<br />
 <br />
Bilateral trade with Israel last year amounted to US$1.3 billion. Israel&#8217;s exports amounted to US$636, compared to US$490 in 2010. Thailand exports to Israel amounted to US$680, compared to US$647 IN 2012. Thailand export mostly vehicles, parts and accessories, sugar, chemicals, plastic pellets and food products to the Israeli market. Israel exports include electronics, machinery, optical equipment, diamonds and chemicals.</p>
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		<item>
		<title>Israeli National Pavilion @ IBC 2012</title>
		<link>http://www.israeltrade.org.au/israeli-national-pavilion-ibc-2012/</link>
		<comments>http://www.israeltrade.org.au/israeli-national-pavilion-ibc-2012/#comments</comments>
		<pubDate>Tue, 15 May 2012 04:00:59 +0000</pubDate>
		<dc:creator>ITC Sydney</dc:creator>
				<category><![CDATA[Events & Exhibitions]]></category>
		<category><![CDATA[Israeli National Pavilions Abroad]]></category>
		<category><![CDATA[Upcoming Events]]></category>

		<guid isPermaLink="false">http://www.israeltrade.org.au/?p=11505</guid>
		<description><![CDATA[Israeli National Pavilion @ IBC 6 &#8211; 11 September 2012 @ Amsterdam RAI This year, there are 22 Israeli companies exhibiting at IBC in Amsterdam. The Israel Trade Commission encourages any Australian company who is heading to IBC 2012 to be in contact with us to see what solutions Israeli Technology has to offer. The Israeli [...]]]></description>
			<content:encoded><![CDATA[<p><strong><a href="http://www.israeltrade.org.au/wp-content/uploads/2012/05/IBC-Pic.jpg"><img class="alignnone size-full wp-image-11506" title="IBC Pic" src="http://www.israeltrade.org.au/wp-content/uploads/2012/05/IBC-Pic.jpg" alt="" width="460" height="209" /></a></strong></p>
<p><strong>Israeli National Pavilion @ IBC</strong></p>
<p><strong>6 &#8211; 11 September</strong> <strong>2012 @ Amsterdam RAI</strong></p>
<p>This year, there are 22 Israeli companies exhibiting at IBC in Amsterdam. The Israel Trade Commission encourages any Australian company who is heading to IBC 2012 to be in contact with us to see what solutions Israeli Technology has to offer.</p>
<p>The Israeli industry is internationally acknowledged as one of the most innovative throughout the world of research and development, both for its basic technology and its applications to the real world.  Israel has the world’s highest concentration of high-tech start-ups per capita.</p>
<p><strong><a href="http://www.israeltrade.org.au/wp-content/uploads/2012/05/company-at-glance-for-IBC-2012-by-category-.pdf" target="_blank">Click here to see a catalogue of the exhibiting Israeli companies</a></strong>.</p>
<p>IBC is the global event that brings together everyone in the world of electronic media. IBC2011 embraced the latest in stereo 3D, high definition TV, over-the-top, on-demand and user-generated content, playing host to more than 1,300 exhibitors and in excess of 50,000 attendees from 140 countries globally.</p>
<p style="text-align: center;">The Israel Trade Commission in Sydney will be happy to pre-arrange one on one meetings for you with any exhibiting Israeli company. For more information on this, please contact Richard Vesely on (02) 9388 0382 or <a href="mailto:richard.vesely@israeltrade.org.au">richard.vesely@israeltrade.org.au</a>.</p>
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		<title>LOTAN SECURITY LTD.</title>
		<link>http://www.israeltrade.org.au/lotan-security-ltd/</link>
		<comments>http://www.israeltrade.org.au/lotan-security-ltd/#comments</comments>
		<pubDate>Tue, 15 May 2012 01:41:43 +0000</pubDate>
		<dc:creator>ITC Sydney</dc:creator>
				<category><![CDATA[Business Opportunities]]></category>
		<category><![CDATA[Security & Safety]]></category>

		<guid isPermaLink="false">http://www.israeltrade.org.au/?p=11503</guid>
		<description><![CDATA[Mass Crowd Events Hosting a Mass Crowd Event likes of, world championships, large concerts, or national rally is a matter of prestige and pride for any host country. Many governments see this opportunity to project the nation on the world stage. The understanding of the host nation that security must be incorporated into all other [...]]]></description>
			<content:encoded><![CDATA[<p>Mass Crowd Events<br />
Hosting a Mass Crowd Event likes of, world championships, large concerts, or national rally is a matter of prestige and pride for any host country. Many governments see this opportunity to project the nation on the world stage. The understanding of the host nation that security must be incorporated into all other aspects of planning is imperative in order to provide a safe and secure event while being cost effective. Securing and protecting public and high profile events that are attended by both large crowds and dignitaries present a challenge for law enforcement as they are attractive soft targets for terrorists who may try to promote their cause and achieve as much media coverage as possible. Lotan&#8217;s &#8220;Major Events Security Implementation&#8221;(MESI) concept enables high level overt and covert proactive security implementation while the secured crowd feels the security just as much as it gives him the sense of security.</p>
<p>Lotan HLS &amp; Defense is an Israeli leading security company with worldwide activity.<br />
Our services focus on three main components: Consulting, Training and Technology assessment.<br />
Our doctrine is built from our experience of many years in the field of HLS and Defense. We are specialized in the fields of Major sport events, facility protection, aviation and transport security and more.<br />
Lotan was recently selected to act as consultants to the Government of Gabon to plan, implement and manage security for the &#8220;2012 African Cup of Nations&#8221;.<br />
We will be happy to take part in the 2015 Asian Cup AUSTRALIA.<br />
I have taken the liberty to attach a short company profile and case study from our project in Gabon.</p>
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		<title>Delek Applies for Cypriot Licenses with Oil Majors</title>
		<link>http://www.israeltrade.org.au/delek-applies-for-cypriot-licenses-with-oil-majors/</link>
		<comments>http://www.israeltrade.org.au/delek-applies-for-cypriot-licenses-with-oil-majors/#comments</comments>
		<pubDate>Tue, 15 May 2012 01:08:40 +0000</pubDate>
		<dc:creator>ITC Sydney</dc:creator>
				<category><![CDATA[News]]></category>
		<category><![CDATA[Top Stories]]></category>

		<guid isPermaLink="false">http://www.israeltrade.org.au/?p=11499</guid>
		<description><![CDATA[Delek units Avner and Delek Drilling have teamed with Australia&#8217;s Woodside, EnergyItaly&#8217;s Enel Trade, and France&#8217;s Edison International. Delek Group Ltd. applied for Cypriot offshore oil and gas exploration licenses on Friday through its gas exploration units Avner Oil and Gas LP and Delek Drilling LP. The companies are part of a consortium with Italy&#8217;s [...]]]></description>
			<content:encoded><![CDATA[<p><strong><a href="http://www.israeltrade.org.au/wp-content/uploads/2012/05/delek.jpg"><img class="alignnone size-full wp-image-11500" title="delek" src="http://www.israeltrade.org.au/wp-content/uploads/2012/05/delek.jpg" alt="" width="325" height="212" /></a></strong></p>
<p><strong>Delek units Avner and Delek Drilling have teamed with Australia&#8217;s Woodside, EnergyItaly&#8217;s Enel Trade, and France&#8217;s Edison International.</strong></p>
<p><a href="http://www.delek-group.com/" target="new">Delek Group Ltd.</a> applied for Cypriot offshore oil and gas exploration licenses on Friday through its gas exploration units <a href="http://www.delek-group.com/Holdings/EnergyInfrastructure/AvnerOilExploration.aspx" target="new">Avner Oil and Gas LP</a> and <a href="http://www.delek-group.com/Holdings/EnergyInfrastructure/DelekDrilling.aspx" target="new">Delek Drilling LP</a>. The companies are part of a consortium with Italy&#8217;s Enel Trade SpA, France&#8217;s Edison International SpA, and Australia&#8217;s Woodside Energy Holdings Pty Ltd.</p>
<p><a href="http://www.nobleenergyinc.com/" target="new">Noble Energy Inc.</a> did not file any bids for the Cypriot licenses, according to the Cypriot media.</p>
<p>Woodside and Edison International each own 30% of the consortium, Enel owns 15%, and Avner and Delek Drilling each own 12.5%. This arrangement may lead to foreign participation in Leviathan, which Delek owns with Noble Energy and Ratio Oil Exploration (1992) LP as some the companies have assets that Delek lacks. Edison International owns a gas pipeline in Europe, and Woodside specializes in liquefied natural gas (LNG infrastructures development.</p>
<p>Enel SpA (BIT: ENEL) and Edison International (a subsidiary of EDF SA) are two of Europe&#8217;s largest energy companies.</p>
<p>Cyprus Opportunity, owned by Rony Halman and Uri Aldubi, a sister company of <a href="http://www.oilandgas.co.il/" target="new">Israel Opportunity Energy Resources LP</a>, has bid for two of the Cypriot licenses, together with Norway&#8217;s AGR Group Inc.</p>
<p>Modiin Energy LP (TASE:<a href="javascript:viewInstrument('345017',45,'EN')">MDIN.L</a>), Isramco Ltd. (Nasdaq: <a href="javascript:viewInstrument('ISRL',11,'EN')">ISRL</a>; TASE: <a href="javascript:viewInstrument('232017',45,'EN')">ISRA.L</a>) affiliate Naphtha Israel Petroleum Corp. (TASE: <a href="javascript:viewInstrument('274019',45,'EN')">NFTA</a>), <a href="http://www.atpog.com/" target="new">ATP Oil &amp; Gas Corporation</a>, and Dor Chemicals Ltd. also filed a joint bid in the tender.</p>
<p>A consortium of Alon Natural Gas Exploration Ltd., Sigma Exploration Ltd., and Cyprus&#8217;s Petrolina (Holdings) Public Ltd. filed bids for Blocks 2 and 9.</p>
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		<title>The enzyme that sharpens memory</title>
		<link>http://www.israeltrade.org.au/the-enzyme-that-sharpens-memory/</link>
		<comments>http://www.israeltrade.org.au/the-enzyme-that-sharpens-memory/#comments</comments>
		<pubDate>Tue, 15 May 2012 01:06:00 +0000</pubDate>
		<dc:creator>ITC Sydney</dc:creator>
				<category><![CDATA[Latest News Israel]]></category>

		<guid isPermaLink="false">http://www.israeltrade.org.au/?p=11287</guid>
		<description><![CDATA[As reported in Israel21c: Imagine never forgetting a single detail of your life — what you got for your 14th birthday, or the phone numbers of every one of your romantic interests. New science from Israel shows that this might be in the realm of possibility. The big question is: Would it be good for [...]]]></description>
			<content:encoded><![CDATA[<p><a href="http://www.israeltrade.org.au/wp-content/uploads/2012/04/weizmann-institute-668x288.jpg"><img class="alignnone size-medium wp-image-11288" title="weizmann-institute-668x288" src="http://www.israeltrade.org.au/wp-content/uploads/2012/04/weizmann-institute-668x288-300x129.jpg" alt="" width="300" height="129" /></a></p>
<p>As reported in Israel21c:</p>
<p>Imagine never forgetting a single detail of your life — what you got for your 14th birthday, or the phone numbers of every one of your romantic interests. New science from Israel shows that this might be in the realm of possibility. The big question is: Would it be good for us?</p>
<p>The breakthrough Israeli-US research project, for the first time anywhere, has found a compound in the brain to enhance memory. Whether the enzyme responsible could ever be made into a “super pill” (like the one imagined in the science-fiction flick Limitless to boost brainpower) is quite speculative, says <strong><a href="http://www.weizmann.ac.il/neurobiology/labs/dudai/pages/members/reut_shema.html">Reut Shema</a></strong> from Israel’s Weizmann Institute of Science.</p>
<p>As a doctoral student, she looked for a way to enhance rats’ memories by altering a naturally occurring protein. Her surprising research findings, published in the prestigious journal <em><a href="http://www.sciencemag.org/content/331/6021/1207">Science</a></em>, may pave the way for memory-enhancement drugs for people suffering from conditions such as Alzheimer’s disease, or to modulate the effects of traumatic memories.</p>
<p>But perhaps most significant are the invaluable clues her research provides on how the memory mechanism really works.</p>
<p><strong>A first for science</strong></p>
<p>Discovering that rats’ memories could be augmented by the enzyme protein kinase M zeta (PKMzeta) was pretty much a surprise, she tells ISRAEL21c. No other lab in the world had been able to demonstrate similar results in animal models.</p>
<p>The researchers conditioned rats to connect the taste of sweet water to a feeling of nausea by adding lithium to the water, creating a weak memory and a negative association to that memory. After a week of training — the equivalent of about 20 months on a human time scale — the researchers injected the rats with a virus, causing an increase in PKMzeta. That’s when the rats’ negative association to sweetness increased.</p>
<p>Previously, inhibiting PKMzeta in the brain has been shown to wipe out the long-term memory of rats. Shema’s project in collaboration with Dr. Todd Sacktor, a neurology professor at SUNY Downstate Medical Center in New York, explored what would happen if the levels of PKMzeta were instead increased. They guessed that memory would also be wiped out, but the opposite occurred.</p>
<p>PKMzeta, which shows up between synapses of the brain, seems to boost the signals between neurons by improving their connectivity. This points to a channel in the brain that could strengthen memories that fade over time.</p>
<p>“There is a lot that needs to be done before it becomes a drug,” Shema tells ISRAEL21c. “We are definitely hoping that it will lead in that direction. But we need to make clear that there is no activator for PKMzeta. We increased the level of the protein [in animal models] but that cannot yet be done in humans,” she explains. “You would need gene therapy, and there is a lot of research that would need to be done first to increase the enzyme activity.”</p>
<p><strong>Why do we remember, anyway?</strong></p>
<p>Whether or not such a memory-enhancing drug should be used on normal, healthy populations is a controversial issue, Shema cautions. There would likely be undesirable side effects, both biochemical and psychological.</p>
<p>“There is good reason why we don’t remember everything that we do,” she says. “And this is why we were surprised that we could show that we could increase memory on healthy rats.”</p>
<p>Memories help us think about the past — not so much to remind us about the fun we had in first grade but to help us adapt to our current environment so we can handle it better, she adds.</p>
<p>“Memory is more about the future than the past. And for that we don’t need a super memory. … Instead, memory needs to be very dynamic and react to the environment. Every time you retrieve a memory it changes it a little. It adapts to the situation.”ore study is needed on how this enzyme works. The next step will be to test it on rats with induced Alzheimer’s symptoms, Shema says. But this avenue of research will be pursued by other scientists, since Shema has finished her PhD in Israel and will be moving to the Broad Institute in the United States to work on neurodegenerative diseases as part of her post-doctoral experience.</p>
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